isotype switchings การใช้

Th2 also produce Interleukin 4, which facilitates B cell isotype switching.
SAg activation in T-cells leads to production of CD40 ligand which activates isotype switching in B cells to IgG and IgM and IgE.
Jak-STAT signal transduction pathway characterized in the activation of cytokine receptors implicated in, for example, in the B cell isotype switching pathway.
B cells are certainly involved in this immune response when IgG class ADA are observed, because antibody isotype switching is a hallmark of B-dependent antigens.
More importantly, FO B cells require CD40-CD40L dependent T FH cell help to promote effective primary immune responses and antibody isotype switching and to establish high-affinity B cell memory.